Table 2. Relationships between C0 and adverse events.

	Hand foot syndrome		Thrombocytopenia		Hypertention		Hypothiroidism		Fatigue
	(G0 vs ≥ G1)		(G0 vs ≥ G1)		(G0 vs ≥ G1)		(G0 vs ≥ G1)		(G0 vs ≥ G1)
	Median	p	Median	p	Median	p	Median	p	Median	p
SU C0	48.3 vs 89.5	<0.01	50.8 vs 89.5	0.02	54.8 vs 65.8	0.90	50.8 vs 71.2	0.08	49.6 vs 70.1	0.06
DSU C0	12.9 vs 15.2	0.88	11.9 vs 16.2	0.44	11.7 vs 15.3	0.82	11.7 vs 16.2	0.55	11.7 vs 15.7	0.64
SU + DSU C0	64.2 vs 75.2	<0.01	64.4 vs 75.2	0.01	67.2 vs 77.5	0.82	64.4 vs 94.1	0.07	64.3 vs 91.5	0.16

Abbreviations: G, grade; SU, sunitinib; C0, predose drug concentration; DSU, N-desetyl sunitinib.