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. 2018 May 18;9(38):25193–25205. doi: 10.18632/oncotarget.25391

Figure 6.

Figure 6

(A) Fluo-3 Ca2+ measurement following siRNA knock down of SIK3 in MCF-7 cells. Westernblot analysis to demonstrate SIK3-siRNA knock down efficiency (H/s refers to high salt). (B) Impact of high salt treatment plus SIK3 knock down on intracellular Rhodamine-123 accumulation. (C) Tumorigenicity of high salt passaged breast cancer cells following shRNA knock down of SIK3 expression. Temporal changes in the tumor volume following injection of 5 × 105 MCF-7 and MCF-7s cells into Nu/J (n = 6) mice. (D–G) The mRNA expression of Orai (D), STIM1 (E), P-glycoprotein (F) and SIK3 (G). Data were represented as mean ± SEM, n = 6 per cohort, p < 0.05.