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. 2018 May 18;9(38):25193–25205. doi: 10.18632/oncotarget.25391

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Copyright: © 2018 Babaer et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Fluo-3 Ca²⁺ measurement following Prostratin (8 μM) plus high salt treatment on MCF-7 cells. (B) Impact of high salt plus Prostratin (8 μM) treatment on intracellular Rhodamine-123 accumulation. (C) Tumorigenicity of high salt passaged breast cancer cells following oral administration of prostratin (100 μM). Temporal changes in the tumor volume following injection of 5 × 10⁵ MCF-7 and MCF-7s cells into Nu/J (n = 6) mice. (D–G) The mRNA expression of Orai (D), STIM1 (E), P-glycoprotein (F) and SIK3 (G). Data were represented as mean ± SEM, n = 6 per cohort, p < 0.05.