Table 1. Number and age at diagnosis of breast and ovarian cancer cases in BRCA1, BRCA2, and non-carrier probands and first-degree relatives.
| No. breast cancer | Age at diagnosis | Age at diagnosis | No. ovarian cancer | Age at diagnosis | Age at diagnosis | |
|---|---|---|---|---|---|---|
| No. (%) | Mean (SE) | Median (IQR) | No. (%) | Mean (SE) | Median (IQR) | |
| Probands | ||||||
| BRCA1 | 58 (87.9) | 41.8 (1.2) | 40 (35-48) | 17 (25.8) | 47.1 (2.0) | 45 (41-52) |
| BRCA2 | 83 (98.8) | 43.4 (0.9) | 42 (37-49) | 4 (4.8) | 46.5 (0.9) | 46 (45.5-47.5) |
| Non-carrier | 1457 (98.1) | 44.8 (0.3) | 44 (38-50) | 35 (2.4) | 40.6 (1.9) | 43 (33-49) |
| First-Degree Relatives with known BRCA status | ||||||
| BRCA1 | 49 (21.3) | 45.1 (1.8) | 42 (36-53) | 20 (8.7) | 50.4 (1.6) | 50 (45-55) |
| BRCA2 | 63 (20.4) | 45.8 (1.5) | 45 (38-50) | 5 (1.6) | 66.0 (4.8) | 62 (61-69) |
| Non-carrier | 456 (8.4) | 51.1 (0.5) | 50 (44-58) | 42 (0.8) | 49.0 (2.4) | 49 (35-60) |
IQR: Interquartile range.