Table 4. Age-specific penetrance of ovarian cancer (× 100) by BRCA1 and BRCA2 mutation status, estimated using data from the first-degree relatives by the modified kin-cohort method.
| BRCA1 carrier | BRCA2 carrier | Non-carrier | |
|---|---|---|---|
| Age Interval | Penetrance (%) (95% CI) | Penetrance (%) (95% CI) | Penetrance (%) (95% CI) |
| 30-50 years | 5.0 (1.8-13.3) | - | 0.4 (0.2-0.6) |
| 30-60 years | 13.7 (6.6-24.3) | 1.31 | 0.7 (0.4-1.0) |
| 30-70 years | 21.5 (10.4-37.1) | 7.31 | 1.4 (0.9-1.9) |
1Number of events too small to allow for reasonable estimates of confidence intervals.