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. 2018 May 18;9(38):24950–24969. doi: 10.18632/oncotarget.25116

Figure 3. SMAD4 is expressed in microglia associated with human glioblastoma samples.

Figure 3

An analysis of the TCGA profiling data reveals a significant increase in SMAD4 mRNA levels in brain glioblastoma tissue as compared to normal non-malignant tissue (A). Panel shows expression of SMAD4 in human glioblastoma tumor tissue (GB 34) (B). Note that there is evident expression of SMAD4 (red) expression in Iba1 positive microglial cells (green). Cell nuclei are labelled with DAPI (blue). Scale=30μm (low magnification), Scale=10μm (high magnification). Table depicts the percentage of Iba1 positive microglial cells per tumor (C).