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. 2018 Apr 24;8(6):2027–2041. doi: 10.1534/g3.118.200192

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Copyright © 2018 Shukla et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Caspase is activated in brwl mutants. (A-C) brwl^KG0/brwl^MI0 mutants are positive for apoptosis as stained by apoptotic marker cleaved caspase-3 (Casp 3). The intensity of staining is enhanced as the fly grows older. 18 day old animals (C) show 100% ovarioles with activated caspase. DAPI (blue), Phalloidin (green) and activated caspase-3 (red) stained ovarioles. (D) Quantitative data representing the percentage of ovarioles that show the Casp 3 staining on third, tenth and eighteenth day after the fly eclosion. Ovaries from three day old brwl^MIO/brwl^KGO animals were used as a control for statistical analyses. N = 3-15, n = 15-40.