Table 8. Mean RF 10-fold CV prediction performance based on side chain polarities of the native and new amino acids at the mutated position.

New/native	Polar			Apolar			Charged			All
	BAR	MCC	%	BAR	MCC	%	BAR	MCC	%	BAR	MCC	%
Polar	0.92	0.84	13	0.89	0.75	11	0.92	0.85	6	0.91	0.81	30
Apolar	0.88	0.78	13	0.88	0.75	8	0.93	0.85	6	0.89	0.79	27
Charged	0.92	0.85	20	0.91	0.81	16	0.84	0.68	7	0.90	0.81	43
All	0.91	0.83	46	0.90	0.78	35	0.89	0.79	19	0.90	0.81	100