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. 2018 May 28;11:3159–3166. doi: 10.2147/OTT.S161807

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© 2018 Wang et al. This work is published and licensed by Dove Medical Press Limited

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Knockdown of CEACAM6 inhibits osteosarcoma cell migration and invasion.

Notes: Western blot (A) and real-time PCR (B) analysis of CEACAM6 expression in the constructed MG-63 and U-2 OS cells. α-Tubulin was used as a protein loading control, and mRNA expression was normalized to GAPDH. (C) Quantification of wound-healing assays for the indicated cell lines after 24 h. (D) Representative micrographs (left panel) and quantification (right panel) of the invasiveness of indicated cells in the transwell matrix penetration assays. Data represent the mean ± SD of three independent experiments; *P<0.05.

Abbreviations: CEACAM6, carcinoembryonic antigen-related cell adhesion molecule 6; OS, overall survival; PCR, polymerase chain reaction.