Table 1.
Predictive lncRNAs involved in response to cisplatin
| lncRNAs | Role in response | Targets | Mechanisms | Cancers | Ref |
|---|---|---|---|---|---|
| AC023115.3 | S | miR-26a/GSK3β | ceRNA | Glioblastoma | 76 |
| AK022798 | R | MRP1, P-gp | N/A | Gastric cancer | 39 |
| AK126698 | R | Wnt/β-catenin | N/A | NSCLC | 69 |
| ANRIL | R | MDR1, MRP1 | N/A | Gastric cancer | 41 |
| ANRIL | R | let-7a | N/A | Nasopharyngeal carcinoma | 50 |
| CASC2 | S | miR-21/PTEN | ceRNA | Cervical cancer | 80 |
| ENST00000457645 | S | Bax, caspase-3 | N/A | Ovarian cancer | 59 |
| GAS5 | S | miR-21/PI3K/Akt | ceRNA | Cervical cancer | 83 |
| GAS5 | S | miR-21/PTEN | ceRNA | NSCLC | 81 |
| HOTAIR | R | NF-κB | By decreasing Iκ-Bα | Ovarian cancer | 48 |
| HOTAIR | R | p21Waf1/Cip1 | N/A | Lung adenocarcinoma | 49 |
| HOTAIR | R | Beclin-1, MDR, and P-gp | N/A | Endometrial cancer | 74 |
| HOTAIR | R | Klf4 | N/A | NSCLC | 78 |
| HOTTIP | R | Wnt/β-catenin | N/A | Osteosarcoma | 71 |
| H19 | R | NRF2 | N/A | Ovarian cancer | 46 |
| H19 | R | FAS, BAK, BAX | N/A | Lung adenocarcinoma | 58 |
| LINC00161 | S | miR-645/IFIT2 | ceRNA | Osteosarcoma | 79 |
| MEG3 | S | p53, β-catenin, survivin, Bcl-xl | N/A | Lung cancer | 53, 54 |
| MEG3 | S | miR-214 | N/A | Ovarian cancer | 63 |
| MEG3 | S | miR-21-5p/SOX7 | ceRNA | NSCLC | 82 |
| NEAT1 | S | CTR1 | ceRNA | Lung cancer | 43 |
| PDAM | S | p53, BCL2L1 | N/A | Glioma | 51 |
| PVT1 | R | MDR1, MRP, mTOR, HIF-1a | N/A | Gastric cancer | 40 |
| PVT1 | R | TGF-β1, p-Smad4, caspase-3 | N/A | Ovarian cancer | 60 |
| ROR | R | p53 | N/A | Nasopharyngeal carcinoma | 52 |
| SFTA1P | S | hnRNP-U-/ADD45A | N/A | LSCC | 64 |
| TRPM2-AS | R | p53-p66shc | N/A | NSCLC | 56 |
| UCA1 | R | miR-196a | Affecting transcription by activating CREB | Bladder cancer | 61 |
| UCA1 | R | Caspase-3, CDK2, surviving, p21 | N/A | Cervical cancer | 62 |
| UCA1 | R | Wnt/β-catenin | N/A | Bladder cancer | 70 |
| XIST | R | miR-17/ATG7 | ceRNA | NSCLC | 75 |
Abbreviations: ABCB1, ATP-binding cassette subfamily B member 1; ABCC1, ATP-binding cassette subfamily C member 1; ABCG2, ATP-binding cassette subfamily G member 2; ceRNA, competing endogenous RNA; CREB, cAMP response element-binding protein; CTR1, copper transporter 1; lncRNAs, long non-coding RNAs; LSCC, lung squamous cell carcinoma; MDR1, multidrug-resistant protein; MRP1, multidrug-resistant-associated protein 1; N/A, not available; NEAT1, nuclear-enriched abundant transcript 1; NSCLC, non-small-cell lung cancer; P-gp, P-glycoprotein; R, resistance; Ref, reference; S, sensitivity.