Table 4.
Independent Predictors of NAFLD‐HCC in 1,127 Patients with NAFLD (cases = 132)
| Model 1 | Model 2 | |||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P Value | OR | 95% CI | P Value | |
| Age, years | 1.18 | 1.13‐1.22 | <0.0001 | 1.18 | 1.09‐1.28 | <0.0001 |
| Sex, M | 1.21 | 0.65‐2.26 | 0.54 | 0.37 | 0.11‐1.30 | 0.12 |
| BMI, kg/m2 | 0.92 | 0.87‐0.96 | 0.002 | 0.89 | 0.78‐1.02 | 0.09 |
| IFG/T2DM, yes | 4.61 | 2.56‐8.28 | <0.0001 | 4.2 | 1.07‐16.5 | 0.04 |
| PNPLA3, I148M alleles | 1.68 | 1.14‐2.46 | 0.008 | 1.14 | 0.51‐2.53 | 0.75 |
| Advanced fibrosis, F3‐F4 | NA | NA | NA | 91.4 | 10.6‐790 | <0.0001 |
| PPPR13B rs4841132, A alleles | 0.22 | 0.07‐0.70 | 0.01 | 1.76 | 0.30‐10.3 | 0.53 |
Comparisons were performed by logistic regression analysis setting HCC as the dependent variable. Model 1 was adjusted for age, sex, BMI and T2DM, PNPLA3, TM6SF2, MBOAT7 rs643718, and PPP1R3B rs4841132 genetic variants. Model 2 was further adjusted for presence of advanced fibrosis.
Abbreviations: BMI, body mass index; IFG, impaired fasting glucose; NA, not addressed; T2DM, type 2 diabetes mellitus.