Table 3.

Contraindications to the use of KDT

Absolute

Carnitine deficiency (primary)

Carnitine palmitoyltransferase (CPT) I or II deficiency

Carnitine translocase deficiency

β‐oxidation defects

Medium‐chain acyl dehydrogenase deficiency (MCAD)

Long‐chain acyl dehydrogenase deficiency (LCAD)

Short‐chain acyl dehydrogenase deficiency (SCAD)

Long‐chain 3‐hydroxyacyl‐CoA deficiency

Medium‐chain 3‐hydroxyacyl‐CoA deficiency.

Pyruvate carboxylase deficiency

Porphyria

Relative

Inability to maintain adequate nutrition

Surgical focus identified by neuroimaging and video‐EEG monitoring

Parent or caregiver noncompliance

Propofol concurrent use (risk of propofol infusion syndrome may be higher)