Table 1.

TFEB full KO line and tissue‐specific conditional KO and conditional overexpression lines that were generated to explore the physiological role of TFEB in specific organs and tissues

Mouse line	Tissue	Phenotype	References
Loss of function
Full KO	Ubiquitous	Embryonic lethality (E9.5)	Steingrimsson et al (1998)
Conditional KO	Bone (CtsK‐Cre)	Defective bone resorption	Ferron et al (2013)
Conditional KO	Liver (Alb‐Cre)	Impaired liver metabolism, metabolic imbalance, exacerbated obesity	Settembre et al (2013a) and Pastore et al (2017)
Conditional KO	Macrophages (Lys2‐Cre)	Impaired inflammatory and immune response	Pastore et al (2016)
Conditional KO	Muscle (Mlc1f‐Cre)	Impaired mitochondrial function and glucose homeostasis	Mansueto et al (2017)
Conditional KO	Intestinal epithelium (Villin‐Cre)	Exacerbated colitis	Murano et al (2017)
Conditional KO	Endothelial cells (VE‐Cad‐Cre)	Decreased angiogenesis and attenuated blood flow recovery after ischemic injury	Fan et al (2018)
Gain of function
Transgenic	Brain (Thy1 promoter)	Clearance of toxic aggregates in an AD model	Wang et al (2016)
Conditional transgenic	Muscle (HSA‐Cre‐Er)	Increased glucose and lipid metabolism	Mansueto et al (2017)
Conditional transgenic	Kidney (Cdh16‐Cre; Cdh16‐Cre‐Ert2)	Renal cystic pathology and papillary carcinoma	Calcagni et al 16)
Conditional transgenic	Macrophages (LyzM‐Cre)	Enhanced degradative capacity, reduced atherosclerosis in ApoE null mice	Sergin et al (2016)
Transgenic	Endothelial cells (Tie2 promoter)	Increased angiogenesis and improved blood flow recovery after ischemic injury	Fan et al (2018)