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Mechanisms by which RTKs locally regulate the adherens junction complex. RTKs can phosphorylate multiple components of the adherens junction, either directly or through the activation of kinases such as Src, Abl, and PAK. These phosphorylation events are generally thought to weaken cell–cell adhesion, by disrupting the association of cadherins to the actin cytoskeleton (left panel), by inducing cadherin endocytosis (right panel), or both.
