Figure 3.

Control of RTKs by junctional cues. (A) Organogenesis in the Danio rerio lateral line primordium occurs through the sequential deposition of rosette-like mechanosensory organs by collectively migrating epithelial cells. Apical constriction and microlumen formation within the rosette restricts the secretion of FGF to the luminal cells, leading to the coordination and enhancement of FGF signaling in a feedback loop that regulates the frequency of organ deposition. (B) The transduction of mechanical forces in response to cell–cell contact can regulate the contact-dependent inhibition of cell proliferation through the control of EGFR signaling. Studies have shown that EGFR signaling is inhibited by the establishment of cell–cell contact through a mechanosensitive mechanism. This inhibition of EGFR can be overridden by experimentally increasing the forces exerted on adherens junctions.