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. 2018 Jun;10(6):a033274. doi: 10.1101/cshperspect.a033274

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Figure 3. — Regulation of TGF-β family expression during axis patterning. Gene activation and repression in (A) early blastula (sphere to shield stage) and (B) the gastrula (after shield stage). Direct activators and repressors are marked by black lines. Indirect activators and repressors, and activators and repressors without sufficient evidence to prove a direct relationship, are marked by gray lines. Genes are color coded by their expression domains. References providing evidence for each relationship or expression domain are listed on the line connecting two genes or in the box with the gene name. Chd, Chordin; Dact2, Dapper homolog 2; Gsc, Goosecoid; Nog, Noggin; Spry, Sprouty. Numbers 1–91 in panels A and B refer to the following references: 1, Bassett et al. 2014; 2, Chamorro et al. 2005; 3, Chen and Schier 2002; 4, Chen and Shen 2004; 5, Cheng et al. 2004; 6, Cheyette et al. 2002; 7, Choi et al. 2007; 8, Dal-Pra et al. 2006; 9, Dougan 2003); 10, Erter et al. 2001; 11, Feldman et al. 1998; 12, Feldman et al. 2002; 13, Flores et al. 2008; 14, Furthauer et al. 2001; 15, Furthauer et al. 2002; 16, Furthauer et al. 2004; 17, Gilardelli et al. 2004; 18, Gore et al. 2005; 19, Gritsman et al. 1999; 20, Gritsman et al. 2000; 21, Hammerschmidt et al. 1996a; 22, Hashimoto et al. 2000; 23, Imai et al. 2001; 24, Joore et al. 1996; 25, Kawahara et al. 2000b; 26, Kawahara et al. 2000a; 27, Kelley et al. 2000; 28, Khan et al. 2012; 29, Kim et al. 2000; 30, Koos and Ho 1999; 31, Kovalenko et al. 2006; 32, Kuo et al. 2013; 33, Lekven et al. 2001; 34, Lele et al. 2001; 35, Leung 2003; 36, Lippok et al. 2014; 37, Lu et al. 2011; 38, Maegawa et al. 2006; 39, Melby et al. 2000; 40, Meno et al. 1999; 41, Miller-Bertoglio et al. 1997; 42, Moreno-Ayala et al. 2015; 43, Nojima et al. 2004; 44, Nguyen et al. 1998; 45, Onichtchouk et al. 2010 46, Pelegri and Maischein 1998; 47, Peng and Westerfield 2006; 48, Pezeron et al. 2006 49, Ramel and Hill 2013; 50, Ramel and Lekven 2004; 51, Ramel et al. 2005; 52, Reim and Brand 2006; 53, Reim et al. 2004; 54, Ro and Dawid 2009; 55, Ro and Dawid 2010; 56, Schneider et al. 1996; 57, Schmid et al. 2000; 58, Seiliez et al. 2006; 59, Shimizu et al. 2000; 60, Shimizu et al. 2002; 61, Shinya et al. 2000; 62, Sirotkin et al. 2000; 63, Solnica-Krezel and Driever 2001; 64, Su et al. 2007; 65, Takeda et al. 1994; 66, Tendeng and Houart 2006; 67, Tsang et al. 2000; 68, Tsang et al. 2002; 69, Tucker et al. 2008; 70, van Boxtel et al. 2015; 71, Varga et al. 2007; 72, Waxman et al. 2004; 73, Waxman 2005; 74, Willot et al. 2002; 75, Xue et al. 2014; 76, Zhang et al. 2004; 77, Belting et al. 2011; 78, Hild et al. 1999; 79, Schulte-Merker et al. 1997; 80, Xie and Fisher 2005; 81, Wang et al. 2013; 82, Xue et al. 2014; 83, Branam et al. 2010; 84, Sidi et al. 2003; 85, Connors et al. 1999; 86, Leyns et al. 1997; 87, Yamanaka et al. 1998; 88, Ryu et al. 2001; 89, Dickmeis et al. 2001; 90, Fekany-Lee et al. 2000; 91, Kapp et al. 2013.

Figure 3. — Regulation of TGF-β family expression during axis patterning. Gene activation and repression in (A) early blastula (sphere to shield stage) and (B) the gastrula (after shield stage). Direct activators and repressors are marked by black lines. Indirect activators and repressors, and activators and repressors without sufficient evidence to prove a direct relationship, are marked by gray lines. Genes are color coded by their expression domains. References providing evidence for each relationship or expression domain are listed on the line connecting two genes or in the box with the gene name. Chd, Chordin; Dact2, Dapper homolog 2; Gsc, Goosecoid; Nog, Noggin; Spry, Sprouty. Numbers 1–91 in panels A and B refer to the following references: 1, Bassett et al. 2014; 2, Chamorro et al. 2005; 3, Chen and Schier 2002; 4, Chen and Shen 2004; 5, Cheng et al. 2004; 6, Cheyette et al. 2002; 7, Choi et al. 2007; 8, Dal-Pra et al. 2006; 9, Dougan 2003); 10, Erter et al. 2001; 11, Feldman et al. 1998; 12, Feldman et al. 2002; 13, Flores et al. 2008; 14, Furthauer et al. 2001; 15, Furthauer et al. 2002; 16, Furthauer et al. 2004; 17, Gilardelli et al. 2004; 18, Gore et al. 2005; 19, Gritsman et al. 1999; 20, Gritsman et al. 2000; 21, Hammerschmidt et al. 1996a; 22, Hashimoto et al. 2000; 23, Imai et al. 2001; 24, Joore et al. 1996; 25, Kawahara et al. 2000b; 26, Kawahara et al. 2000a; 27, Kelley et al. 2000; 28, Khan et al. 2012; 29, Kim et al. 2000; 30, Koos and Ho 1999; 31, Kovalenko et al. 2006; 32, Kuo et al. 2013; 33, Lekven et al. 2001; 34, Lele et al. 2001; 35, Leung 2003; 36, Lippok et al. 2014; 37, Lu et al. 2011; 38, Maegawa et al. 2006; 39, Melby et al. 2000; 40, Meno et al. 1999; 41, Miller-Bertoglio et al. 1997; 42, Moreno-Ayala et al. 2015; 43, Nojima et al. 2004; 44, Nguyen et al. 1998; 45, Onichtchouk et al. 2010 46, Pelegri and Maischein 1998; 47, Peng and Westerfield 2006; 48, Pezeron et al. 2006 49, Ramel and Hill 2013; 50, Ramel and Lekven 2004; 51, Ramel et al. 2005; 52, Reim and Brand 2006; 53, Reim et al. 2004; 54, Ro and Dawid 2009; 55, Ro and Dawid 2010; 56, Schneider et al. 1996; 57, Schmid et al. 2000; 58, Seiliez et al. 2006; 59, Shimizu et al. 2000; 60, Shimizu et al. 2002; 61, Shinya et al. 2000; 62, Sirotkin et al. 2000; 63, Solnica-Krezel and Driever 2001; 64, Su et al. 2007; 65, Takeda et al. 1994; 66, Tendeng and Houart 2006; 67, Tsang et al. 2000; 68, Tsang et al. 2002; 69, Tucker et al. 2008; 70, van Boxtel et al. 2015; 71, Varga et al. 2007; 72, Waxman et al. 2004; 73, Waxman 2005; 74, Willot et al. 2002; 75, Xue et al. 2014; 76, Zhang et al. 2004; 77, Belting et al. 2011; 78, Hild et al. 1999; 79, Schulte-Merker et al. 1997; 80, Xie and Fisher 2005; 81, Wang et al. 2013; 82, Xue et al. 2014; 83, Branam et al. 2010; 84, Sidi et al. 2003; 85, Connors et al. 1999; 86, Leyns et al. 1997; 87, Yamanaka et al. 1998; 88, Ryu et al. 2001; 89, Dickmeis et al. 2001; 90, Fekany-Lee et al. 2000; 91, Kapp et al. 2013.