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. 2018 Apr 27;12(6):814–829. doi: 10.1002/1878-0261.12191

Figure 3.

Figure 3

CpG island/promoters of genes repressed in PB CD34+ cells tend to be hypermethylated in CP‐CML CD34+ CD15− cells. (A) Distribution of probes in hypermethylated CGI‐associated DMRs according to their chromatin signatures in hESCs (left panel) and PB (PB) CD34+ cells (right panel), respectively. The distribution of all HM450K probes at CGIs according to their chromatin signature in hESC and PB‐CD34+ cells, respectively, is shown as reference. (B) Genes with aberrantly hypermethylated CGI/promoter in CP‐CML CD34+ CD15− cells tend to be repressed in PB‐CD34+ cells. Boxplot representation of the expression levels in PB‐CD34+ cells for genes with unaffected and hypermethylated CGI/promoter‐associated DMRs, respectively, in CML CD34+ CD15− cells (Mann–Whitney test).