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. 2018 May 12;10(5):198. doi: 10.3390/toxins10050198

Scheme 1.

Scheme 1

Schematic illustration of the fluorescent aptamer sensor for OTA. In the absence of OTA, OTA-Aptamer can form a G-quadruplex structure with thioflavin T (ThT), which results in enhanced fluorescence. After addition of OTA, OTA-Aptamer specifically binds to OTA and forms the G-quadruplex. After this quadruplex has a weak reaction with ThT, weak fluorescence is observed.