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Role of RyR in the EC effect on A375 cell viability. Cells were exposed at 1, 3 and 10 μM EC for 24 h, in the presence or absence of the RyR antagonist dantrolene, at 25, 50 and 75 μM. Data are the mean ± SD from three independent experiments. *** p < 0.001; one-way ANOVA followed by Dunnett’s multiple comparison test.
