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. 2018 May 14;128(6):2600–2612. doi: 10.1172/JCI98709

Figure 2. PPARγ deacetylation promotes thermogenic responses.

Figure 2

(A–D) Calorimetric analyses of 4-month-old male mice fed a chow diet during acute cold exposure (day 1) and after chronic cold exposure (day 5). (A) Food intake. (B) RER. (C) Oxygen consumption and (D) heat production. *P < 0.05 at multiple detection points. n = 9 WT; n = 11 2KR (2 WT and 1 mutant mice were hypothermic at the cold exposure and terminated). (E and F) qPCR analyses of gene expression in iWAT (E) and BAT (F) of 5- to 6-month-old chow-fed male mice after 5-day cold exposure. *P < 0.05; **P < 0.01 for WT vs. 2KR. n = 6 WT; n = 6 2KR. (G) qPCR analyses of gene expression in iWAT primary adipocytes after 4-hour forskolin (5 μM) treatment. *P < 0.05; **P < 0.01 for WT vs. 2KR. n = 5 WT; n = 5 2KR. Data represent mean ± SEM. Student’s t test was used for statistical analyses.