Figure 3. Comparison of the Fah^–/– TRAP-seq data with RNA-seq data from the PHx model identifies common and unique characteristics of liver repopulation paradigms.

(A) A total of 1,236 genes were significantly altered in the same direction in both models (36) for at least 1 time point (congruent genes). Of these genes, 790 were activated and 446 inhibited. Labels indicate the number of congruent genes at each time point. (B) A total of 5,510 and 1,033 genes were uniquely changed in the Fah^–/– and PHx models, respectively. (C and D) Comparison of the KEGG pathways enriched for genes upregulated (C) and downregulated (D) in the congruent (Cong) and unique gene sets.