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. 2018 May 7;128(6):2473–2486. doi: 10.1172/JCI96121

Figure 7. UHRF1 binding on VSMC differentiation genes.

Figure 7

(A) ChIP assay showing UHRF1 enrichment at the Myh11, Acta2, Cnn1, and Sm22 promoters during VSMC dedifferentiation. Mouse primary VSMCs were cultured in a serum-deprived condition (0.1% FBS) or with 10% FBS. (B) Methyl ChIP assay showing reduced methylation at the Myh11, Acta2, Cnn1, and Sm22 promoters in the absence of Uhrf1. (C) ChIP assay showing H3K27me3 enrichment at the Myh11, Acta2, Cnn1, and Sm22 promoters in the absence of Uhrf1. Data are presented as mean relative enrichment over input ± SD of 3 biological repeats. To compare means, unpaired 2-tailed Student’s t test was used. #P < 0.05.