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. 2018 May 7;128(6):2519–2534. doi: 10.1172/JCI97053

Figure 8. Increased class-switched B cells from aged vPK transgenic versus age-matched WT mice.

Figure 8

(A) Frequency of B220+IgM–IgD– cells WT spleen (3.4%) and vPK with splenic lymphoma (33.7%). (B) Frequency of B220+GL-7+ from the mice shown in A, WT (gray, 2.1%) and vPK (black line, 77.4%). (C) Frequency of B220+IgM–IgD– cells in a mass (vPK1.A, 29.5%), lymphoma spleen (vPK1.B, 78.2%), and mass (vPK1.B, 71.2%). n = 12 vPK. (D) Frequency of B220+GL-7+-expressing cells from the lymphomas shown in C. Gray, unstained, 0.074%; solid line, vPK1.A, 15.1%; dotted line, vPK1.B spleen, 91.7%; dashed line. vPK1.B mass, 89.7%. (E) Representative of frequency of κ/λ B220+ cells from WT spleen and vPK spleen with lymphoma (n = 9 total, 5 spleens and 4 nodes). n = 3 normal WT spleens.