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. Author manuscript; available in PMC: 2018 Jun 1.

Published in final edited form as: Lancet. 2008 Oct 6;372(9652):1828–1834. doi: 10.1016/S0140-6736(08)61348-3

Table 3. Allelic and genotypic tests of rs2511989 from primary screen of UK sample (n=953), US sample (n=500), and the two cohorts combined.

	UK cohort					US cohort				Combined
	Case	Control	OR (95% CI)	Uncorrected p value	Corrected p value^*	Case	Control	OR (95% CI)	p value	Case	Control	OR (95% CI)	p value
Allelic				5.4×10^–6	0·0005				0·0037				7.49×10^–8
G	597 (63%)	500 (52%)	..	..	..	322 (65%)	282 (56%)	..	..	919 (64%)	782 (54%)	..	..
A	355 (37%)	454 (48%)	0·65 (0·55–0·79)^†	..	..	174 (35%)	222 (44%)	0·69 (0·53–0·89)^†	..	529 (37%)	676 (46%)	0·67 (0·57–0·77)^†	..
Genotypic				4.0×10^–5	0·0037				0·0080				6.08×10^–7
GG	191 (40%)	132 (28%)	..	..	..	100 (40%)	79 (31%)	..	..	291 (40%)	211 (29%)	..
GA	215 (45%)	236 (50%)	0·63 (0·47–0·84)^‡	..	..	122 (49%)	124 (49%)	0·77 (0·53–1.14)^‡	..	337 (47%)	360 (49%)	0·68 (0·54–0·86)^‡	..
AA	70 (15%)	109 (23%)	0·44 (0·31–0·64)^‡	..	..	26 (11%)	49 (19%)	0·42 (0·24–0·73)^‡	..	96 (13%)	158 (22%)	0·44 (0·32–0·60)^‡	..

^*

Corrected for 93 single nucleotide polymorphisms.

^†

Relative to G allele.

^‡

Relative to wildtype (GG) homozyte.