Figure 5.
MMP-9 is expressed at elevated levels in A2bAR KO injured femoral arteries. Control and A2bAR KO mice were used at 4 weeks postfemoral artery injury. Immunohistochemistry of MMP-9 in femoral artery sections from the above WT (A) or A2bAR KO mice (A, B). Scale bar = 50 µm; photographed at 400× or 1000× as indicated. Data are representative of three animals per group assayed. Arrows mark the location of MMP-9–positive cells (brown staining) at either the endothelial cell layer facing the lumen or within the inner smooth muscle cell layer.