Table 1. Mechanisms of HIV-1 evasion.

Restriction factors are listed with the major adaptive strategy that HIV-1 employs to evade their restriction.

Restriction Factors	HIV-1 Evasion Mechanism
SAMHD1 [36]	Vpx inhibits SAMHD1 by reqcruting an E3 ligase leading to its ubinylation and degradation
APOBEC3 [67]	Vif inhibits APOBEC by leading to its polyubiquination and proteosomal degradation
MX2 [74]	Capsid mutates to evade interaction with MX2 binding loop
SERINC3/5 [90]	Nef inhibts SERINC3/5 by decreasing its incorporation into virions and redeistributing the proteins into an endocytic compartment
Tetherin [80]	Vpu inhibits trafficking of tetherin to the surface and promotes its ubinylation and degradation