Table 2. Associations between polygenic risk scores for Alzheimer’s disease (FDR p-value ≤ 0.018), amyotrophic lateral sclerosis (FDR p-value ≤ 0.0024), and frontotemporal dementia (FDR p-value ≤ 0.0041), and cognitive and physical measures controlling for age, sex, assessment centre, genotyping batch and array and 10 genetic principal components for population structure.

	Alzheimer's disease			Amyotrophic lateral sclerosis			Frontotemporal dementia
	pT	β	p	pT	β	p	pT	β	p
Verbal-numerical reasoning	0.05	-0.0229	1.27 × 10−5*	0.05	-0.0188	0.0004	1	-0.0085	0.1036
Reaction time	0.5	0.0052	0.0700*	1	0.0023	0.4315	0.5	-0.0033	0.2489
Memory	0.1	0.0114	0.0001*	0.1	0.0080	0.0074	0.05	0.0053	0.0737
Symbol digit substitution	0.5	-0.0150	0.0065	0.01	-0.0063	0.2613	0.01	-0.0053	0.3316
Trail making part A	0.05	0.0144	0.0195	0.01	0.0087	0.1609	0.1	0.0104	0.0900
Trail making part B	0.5	0.0168	0.0047	0.1	0.0155	0.0101	0.1	0.0171	0.0041
Trail making part B-A	1	0.0104	0.0965	0.1	0.0166	0.0091	0.1	0.0093	0.1410
Grip strength	0.1	-0.0016	0.3963	0.01	0.0032	0.0997	0.05	0.0020	0.2911
Forced expiratory volume in 1s	1	-0.0027	0.2018	0.01	0.0022	0.3066	0.05	0.0068	0.0012
Peak expiratory flow	1	-0.0039	0.1159	0.01	0.0017	0.4943	0.1	0.0113	4.77 × 10−6
Forced vital capacity	1	-0.0014	0.4817	0.01	0.0019	0.3158	0.05	0.0027	0.1628

pT, polygenic risk score threshold for best model

*, previously published by Hagenaars et al., (2016) [37]