Table 3. Cognitive and physical variable comparison between high Alzheimer’s disease (AD) polygenic risk, amyotrophic lateral sclerosis (ALS) polygenic risk, and frontotemporal dementia (FTD) polygenic risk, N for each group is shown.
| High Risk AD | High Risk ALS | High Risk FTD | p-value | |
|---|---|---|---|---|
| Age | 56.93 ± 7.81 (n = 389) |
57.24 ± 7.75 (n = 386) |
57.07 ± 7.95 (n = 343) |
0.86 |
| Gender (M/F) | 179/210 | 188/198 | 157/186 | 0.67 |
| Cognitive | ||||
| Trail making part B‡ | 4.10 ± 0.34 (n = 27) |
4.05 ± 0.40 (n = 25) |
4.15 ± 0.24 (n = 17) |
1.00† |
| Verbal-numerical reasoning | 6.50 ± 2.40 (n = 28) |
6.22 ± 1.91 (n = 40) |
6.42 ± 2.02 (n = 24) |
1.00† |
| Memory | 4.12 ± 3.26 (n = 107) |
4.09 ± 2.98 (n = 112) |
3.72 ± 2.73 (n = 103) |
1.00† |
| Symbol digit substitution | 19.77 ± 5.59 (n = 30) |
22.16 ± 5.47 (n = 25) |
17.57 ± 5.34 (n = 21) |
0.04† |
| Physical | ||||
| FEV1 | 2.78 ± 0.70 (n = 112) |
2.84 ± 0.84 (n = 93) |
2.66 ± 0.72 (n = 84) |
0.62† |
| PEF | 383.09 ± 124.25 (n = 92) |
398.06 ± 138.79 (n = 101) |
394.27 ± 125.92 (n = 96) |
0.62† |
‡Log transformed
†Kruskal-Wallis H test; Chi Squared tests used for gender distribution comparison; Mean ± Standard Deviation shown for each high neurodegenerative disease polygenic risk group; bold text indicate significance adjusted for multiple comparisons (Holm-Bonferroni)