Fig 2.

(A) Apoptosis/(Annexin V/PI) (mean±SEM) of KAN0439834 (500 nM) (■) and anti-ROR1 mAb (10 μg/ml) (□) in pancreatic cancer cells after 72 h of incubation. P-values refer to the comparison between anti-ROR1 mAb and KAN0439834 incubated cells. *p = 0.05; **p = 0.01; ***p = 0.001 and ns = not significant. Effects of KAN0439834 (B) and anti-ROR1 mAb (C) on the apoptosis associated proteins MCL-1, Bcl-xL, caspase-3 and PARP proteins after 24 h of incubation. MCL-1 and Bcl-xL proteins were downregulated and caspase-3 and PARP cleaved.