Fig 8. Effects of KAN0439834 and anti-ROR1 mAb on ROR1 associated signaling molecules in the pancreatic cancer cell line PaCa-2.

Western blots showed inhibition of ROR1, LRP6, SRC, PI3Kδ, AKT, mTOR and CREB phosphorylation after incubation (2 h) with (A) KAN0439834 (500 nM) and (B) anti-ROR1 mAb (10 μg/ml). (+) treated cells and (-) untreated cells.