Fig 1. Experimental timeline and histology.

(A) Rats received stereotaxic surgery, recovered, then underwent Pavlovian fear discrimination. The shock probability of the uncertainty cue was increased to p = 0.50 over four sessions, then decreased to p = 0.125 over four sessions. Following the completion of fear testing, rats received voluntary intermittent access to alcohol over eight sessions. (B) A representative control with lOFC intact (left) and lesion with OFC damage (right) is shown. (C) The extent of neurotoxic lOFC lesions across four coronal planes is shown, and the anterior distance from bregma (millimeters) indicated.