Table 1.
Characteristics of participants in the intravenous alcohol self-administration sample
| Measure | Male (N = 56) | Female (N = 50) | ||
|---|---|---|---|---|
| AA (N = 36) | AG/GG (N = 20) | AA (N = 43) | AG/GG (N = 7) | |
| Demographic variables | ||||
| Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | |
| Age | 25.0 (5.0) | 23.5 (5.0) | 23.0 (6.0) | 24.0 (2.0) |
| AUDIT scorea | 6.0 (3.0) | 6.0 (3.5) | 5.0 (4.5) | 6.0 (5.0) |
| Total drinksb | 78.0 (56.1) | 76.5 (57.0) | 61.0 (75.0) | 75.0 (68.0) |
| Average drinks per drinking dayb | 3.3 (1.7) | 3.0 (3.0) | 2.5 (1.7) | 2.2 (2.1) |
| Binge drinking daysb | 3.5 (7.8) | 2.0 (8.8) | 4.0 (9.0) | 5.0 (10.0) |
| Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | |
| Delay discountinga,c | −5.0 (1.8) | −4.7 (2.1) | −4.8 (1.9) | −4.8 (1.3) |
| SRE first fived | 4.8 (2.3) | 4.3 (2.1) | 3.5 (1.2) | 4.6 (3.0) |
| N (%) | N (%) | N (%) | N (%) | |
| Family history positive | 8 (22.2) | 5 (25.0) | 8 (18.6) | 1 (14.3) |
| Outcome variables | ||||
| Median (IQR) | Median (IQR) | Median (IQR) | Median (IQR) | |
| Feel effectse | 21.0 (28.0) | 17.0 (16.5) | 18.0 (30.0) | 22.0 (28.0) |
| Like effectsf | 56.0 (11.8) | 53.5 (12.0) | 52.0 (12.0) | 58.0 (16.0) |
| Feel highg | 11.0 (29.5) | 21.0 (28.5) | 18.0 (31.0) | 14.0 (24.0) |
| Feel intoxicatedh | 16.0 (29.0) | 15.0 (28.5) | 18.0 (33.0) | 22.0 (22.0) |
| Sedation changei | 2.0 (5.0) | 2.0 (7.8) | 1.0 (6.0) | 0.0 (19.0) |
| Total alcohol exposurej,k | 4360.0 (6601.4) | 5662.5 (6268.6) | 1514.3 (5034.4) | 3102.9 (6059.7) |
| Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | |
| Want morel | 44.0 (20.5) | 47.5 (24.6) | 32.9 (20.7) | 42.7 (15.6) |
| Post-prime cravingm | 3.3 (6.4) | 4.2 (6.3) | 2.4 (4.8) | 2.1 (5.3) |
| Stimulation changei | −0.1 (9.8) | 1.7 (6.5) | −1.6 (7.7) | −1.9 (6.5) |
| N (%) | N (%) | N (%) | N (%) | |
| Bingersj,n | 15 (41.7) | 9 (45.0) | 10 (23.8) | 2 (28.6) |
aMissing data for some participants: N = 9 for delay discounting, N = 2 for AUDIT scores.
bTotal drinks, average drinks per drinking day, and binge drinking days over the last 90 days were obtained using the Timeline Followback interview.
cValues are reported as the natural logarithm of the discounting constant.
dTotal score from the Self-Rating of the Effects of Alcohol form (SRE) from the first five drinking occasions.
eMeasured using the “do you feel any drugs effects” item on the Drug Effects Questionnaire (DEQ) following the priming dose of alcohol.
fMeasured using the “do you like the effects you are feeling now” item on the DEQ following the priming dose of alcohol.
gMeasured using the “do you feel high” item on the DEQ following the priming dose of alcohol. hMeasured using the “do you feel intoxicated” item on the DEQ following the priming dose of alcohol.
iBiphasic Alcohol Effects Scale (BAES), change measured as BAES stimulant or sedation subscale score following the priming dose of alcohol minus the corresponding baseline subscale score.
jN=105. One female (genotype = A/A) was excluded from alcohol self-administration analyses as her session ended at minute 41.5 due to technical difficulties.
kTotal alcohol exposure is defined as the area under the curve of the estimated blood alcohol concentration versus time plot.
lMeasured using the “would you like more of what you received, right now” item on the DEQ following the priming dose of alcohol.
mPost-prime craving measured as Alcohol Urge Questionnaire (AUQ) score following the priming dose of alcohol minus AUQ score at baseline.
nA binge during the IV alcohol self-administration session is defined as reaching a software-estimated blood alcohol concentration of 80 mg%