Fig. 3.

Sympathomimetic activity of AMP and MA. X-axis indicates time elapsed from administration of the blinded study capsule. Y-axis indicates systolic blood pressure. Test sessions were 5.5 h in duration. MR spectroscopy was conducted 140–150 min after the capsule was administered (gray shading). Physiological monitoring was conducted at half hour intervals throughout the protocol. Time points of capsule administration, entry into the scanner, initiation of MR spectroscopy, and exit from scanner are indicated. AMP d-amphetamine (solid black line), MA methamphetamine (dashed black line), PBO placebo (dotted gray line). Error bars represent ± 1 SE. ****p ≤ .001, ***p ≤ .005 compared to PBO; ^aAMP and MA differ at p < .05. n = 23 with full data for analysis, see Suppl. Methods for details