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. 2018 May 16;19(5):1480. doi: 10.3390/ijms19051480

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Alox12/15 as the most upregulated factor in FC-iPSC-CMs. (A) Schematic diagram of the MS-based proteomics, showing how candidate markers were identified in FC-iPSC-CMs. (B) Proteome screening of the significantly upregulated candidate markers in FC-iPSC-CMs. (C) Western blotting (left) and its quantification (right) confirmed the upregulation of Alox12/15 in FC-iPSC-CMs. (D) Elevated secretion of 12(S)-HETE and 15(S)-HETE from FC-iPSC-CMs. In (C,D), the results are mean ± S.D. of three independent experiments. In (C), * p < 0.05 vs. Ctrl; in (D), * p < 0.05 vs. Ctrl-iPSC-CM and hESC-CM.