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. 2018 May 7;19(5):1388. doi: 10.3390/ijms19051388

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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AHR inhibitors block human cancer cell metastasis in zebrafish xenograft models. Human RFP-MDA-MB-231 (TNBC), RFP-HSC3 (oral squamous cell carcinoma), or RFP-HeLa (cervical carcinoma) cells were injected into the perivitiline space of two-day-old zebrafish larvae and larvae were treated with vehicle (0.1% DMSO), 10 μM CB7993113 or 10 μM CH223191. Fish were imaged 24 h later at 8.5× magnification by confocal microscopy. (A) Representative images from 9–20 fish/group. (B) The number of fish with one or more metastases. (C) Data are presented as the average number of metastases/fish + SE after treatment with vehicle, CB7993113 (CB) or CH223191 (CH). * p = 0.08, ** p < 0.02, *** p < 0.003.