Table 1.
Somatic growth.
| RA | 50% | 50–12% | 50–21% | 21–12% | |
|---|---|---|---|---|---|
| P14: | |||||
| %Change Wt. | 216.0 ± 8.6 | 241.1 ± 13.4 ** | 198.9 ± 6.6 ** | 236.1 ± 13.6 ** | 251.2 ± 12.0 **# |
| %Change Lgth. | 72.0 ± 2.2 | 62.0 ± 2.8 ** | 45.8 ± 1.4 ** | 55.3 ± 1.4 ** | 54.3 ± 2.0 **## |
| Brain/Body Wt. Ratios | 0.054 ± 0.0016 | 0.052 ± 0.002 | 0.05 ± 0.0014 * | 0.051 ± 0.0015 | 0.048 ± 0.0015 * |
| Lung/Body Wt. Ratios | 0.018 ± 0.0005 | 0.016 ± 0.0007 * | 0.02 ± 0.0009 | 0.02 ± 0.0007 | 0.018 ± 0.0007 |
| P21: | |||||
| %Change Wt. | 317.4 ± 17.4 | 493.9 ± 17.6 ** | 402.1 ± 10.9 ** | 443.1 ± 15.5 ** | 482.2 ± 13.8 **## |
| %Change Lgth. | 94.8 ± 4.0 | 99.1 ± 1.4 ** | 72.3 ± 2.2 ** | 94.2 ± 2.0 | 94.5 ± 3.7 ## |
| Brain/Body Wt. Ratios | 0.05 ± 0.002 | 0.035 ± 0.0009 ** | 0.042 ± 0.0006 ** | 0.037 ± 0.0012 ** | 0.034 ± 0.001 **## |
| Lung/Body Wt. Ratios | 0.014 ± 0.0004 | 0.011 ± 0.0006 ** | 0.013 ± 0.0004 | 0.011 ± 0.0006 ** | 0.01 ± 0.0006 **## |
(n = 18 rats/group; * p < 0.05; ** p < 0.01 vs. RA; # p < 0.05; ## p < 0.01 vs. 50–12% by ANOVA); RA (room air, 21% O2); 50% (hyperoxia, Hx); 50–12% (intermittent hypoxia, IH, resolving in hyperoxia, Hx); 50–21%; 21–12% (intermittent hypoxia, IH, resolving in RA).