Figure 3.

CD5 expression levels in naïve T cells may influence T cell metabolism and function. Differential levels of CD5 result in differences in Ca²⁺ mobilization in naïve T cells. CD5^hi naïve T cells have higher Ca²⁺ influx than CD5^lo naïve T cells upon TCR:pMHC interaction [35]. Ca²⁺ signaling plays a significant role in T cell activation and influences metabolism and T cell function. Differential Ca²⁺ mobilization and expression of calcineurin and NFAT affect glycolysis and mitochondrial respiration (hypothetical levels of metabolic activation are shown with dashed (low) or solid (high) arrows), suggesting CD5 expression may affect metabolic reprograming during T cell activation [141].