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. 2018 May 10;19(5):1433. doi: 10.3390/ijms19051433

Figure 2.

Figure 2

Aberrant signal transduction of GH into the intracellular domain (ICD) of GHR. (a,b) Homodimerization of two GHR or GHBP molecules. (c,d) Heterodimerization of one GHR and one GHBP molecule or/and GH failing to combine in the GHR–GHBP dimer. Only GH (orange circle) site 1 (black rhombus) or 2 (red rhombus) bind successfully to one molecule in these two homodimers that leads to a failure in the formation of the GH–GHR2 complex. ECD: extracellular domain; TMD: transmembrane domain; ICD: intracellular domain of GHR.