Table 1.
VEGFR-1 residues involved in interaction with ligands or dimer formation.
| PDB ID: 1FLT | PDB ID: 2XAC | PDB ID: 1RV6 | |||||
| VEGFR-1 D2 | VEGF-A | VEGFR-1 D2 | VEGF-B | VEGFR-1 D2 | PlGF | ||
| 142 I | 17 F | 141 E | 16 S | 140 S | 25 F | ||
| 143 P | 18 M | 142 I | 17 W | 141 E | 26 Q | ||
| 145 I | 21 Y | 143 P | 21 Y | 142 I | 29 W | ||
| 147 H | 22 Q | 145 I | 22 T | 143 P | 30 G | ||
| 171 K | 25 Y | 172 F | 48 V | 145 I | 33 Y | ||
| 172 F | 46 I | 199 Y | 62 P | 171 K | 71 D | ||
| 173 P | 48 K | 202 I | 63 D | 172 F | 74 L | ||
| 199 Y | 63 D | 203 G | 66 L | 173 P | 89 L | ||
| 204 L | 65 G | 204 L | 79 Q | 199 Y | 91 I | ||
| 221 L | 66 L | 221 L | 81 L | 203 G | 97 P | ||
| 223 H | 81 M | 224 R | 88 S | 204 L | 99 Y | ||
| 224 R | 83 I | 89 Q | 219 N | 114 P | |||
| 225 Q | 86 H | 90 L | 221 L | ||||
| 89 Q | 105 P | 223 H | |||||
| 91 I | 224 R | ||||||
| 105 R | |||||||
| 106 P | |||||||
| PDB ID: 5T89 | PDB ID: 5T89 | PDB ID: 5T89 | Homology Model | ||||
| VEGFR-1 D3 | VEGF-A | VEGFR-1 D4 | VEGFR-1 D4 | VEGFR-1 D5 | VEGFR-1 D5 | VEGFR-1 D7 | VEGFR-1 D7 |
| 226 T | 34 D | 351 R | 351 R | 382 R | 675 S | 675 S | |
| 227 N | 36 F | 379 K | 379 K | 394 D | 676 S | 676 S | |
| 258 L | 40 P | 380 S | 380 S | 429 Q | 429 Q | 677 S | 677 S |
| 259 N | 41 D | 381 A | 381 A | 431 Y | 431 Y | 704 E | 704 E |
| 260 T | 43 I | 382 R | 382 R | 432 E | 432 E | 705 P | 705 P |
| 261 R | 44 E | 393 K | 393 K | 433 K | 433 K | 706 G | 706 G |
| 262 V | 45 Y | 394 D | 434 A | 434 A | 707 I | 707 I | |
| 263 Q | 46 I | 435 V | 435 V | 708 I | 708 I | ||
| 264 M | 63 D | 436 S | 436 S | 717 F | 717 F | ||
| 277 S | 64 E | 437 S | 437 S | 719 E | 719 E | ||
| 278 V | 65 G | 438 F | 438 F | 720 R | 720 R | ||
| 279 R | 84 K | 439 P | 439 P | 722 T | 722 T | ||
| 280 R | 85 P | 451 I | 451 I | 725 D | 725 D | ||
| 282 I | 86 H | 453 T | 453 T | ||||
| 284 Q | 107 K | 455 T | 455 T | ||||
| 287 S | 108 K | 508 R | 508 R | ||||
| 290 N | 510 A | 510 A | |||||
| 292 F | 512 I | 512 I | |||||
| 315 S | 513 E | 513 E | |||||
| 316 G | 517 K | 517 K | |||||
| 317 P | 519 A | 519 A | |||||
| 521 T | 521 T | ||||||
VEGFR-1 residues reported in the table have at least one atom within a specific distance from at least one atom of the indicated ligand. Selected thresholds were: 4.0 Å, in the case of the experimental structures of VEGFR-1 D2 in complex with VEGF-A (PDB ID: 1FLT), VEGF-B (PDB ID: 2XAC), and PlGF (PDB ID: 1RV6), which have been solved with resolution <2.8 Å; and 5.0 Å in the case of the experimental structure of VEGFR-1 D1-D6 (PDB IDs: 5T89), which has been solved with resolution = 4.0 Å, and of the molecular model built by homology for the D7 dimer, using as a template the 3D structure of VEGFR-2 D7-D7 dimer (PDB ID: 3KVQ). The latter threshold was chosen to take into account possible errors in atom positioning due to the low resolution of the structure and inherent the modeling procedure, respectively.