Table 1.

Summary of Tumor Necrosis Factor inhibitorsstructure, transplacental transport, and safety studies in pregnancy.

Biologic Agent, Year of EMA Authorization, (Trade Name)	Structure	Transplacental Transport	Safety Studies
Infliximab, 1999, (Remicade, Remsima, Inflectra)	Chimeric human-murine complete IgG1 mAb	Active transport from gestational week 22 [23]	Bröms et al. 2016 [30] Casanova et al. 2013 [31] Shihab et al. 2016 [32] Weber-Schoendorfer [33]
Etanercept, 2000, (Enbrel, Benepali)	Fc fragment of human IgG1 fusion protein	Some [24]	Bröms et al. 2016 [30] Weber-Schoendorfer [33]
Adalimumab, 2003, (Humira)	Fully human complete IgG1 mAb	Active transport from gestational week 22 [23]	Burmester et al. 2017 [34] Bröms et al. 2016 [30] Casanova et al. 2013 [31] Shihab et al. 2016 [32] Weber-Schoendorfer [33]
Certolizumab, 2009, (Cimzia)	Humanized PEGylated Fab’ IgG fragment of mAb	Minimal [29]	Bröms et al. 2016 [30] Casanova et al. 2013 [31] Mariette et al. 2018 [29] Shihab et al. 2016 [32] Weber-Schoendorfer [33]
Golimumab, 2009, (Simponi)	Fully human complete IgG1 mAb	Active transport from gestational week 22 [35]	Bröms et al. 2016 [30] Weber-Schoendorfer [33]

EMA = European Medicines Agency; IgG = Immunoglobulin G; mAb = monoclonal antibody; Fab = antigen-binding fragment.