Figure 2.

An example of a rescue of dystrophic phenotype in a mouse model for congenital MD. The mouse lacking laminin α2 chain (dy^3K/dy^3K in the left picture) at the terminal stage of the disease shows severe muscle wasting and severe overall phenotype. The laminin α2 chain-deficient littermate overexpressing laminin α1 chain (dy^3K/LMα1) displays significant improvement of multiple aspects of the disease. The laminin α1 transgene prevents MD throughout life (right picture): two-year-old dy^3K/LMα1 and normal littermate mouse present similar outward features.