. 2018 May 18;19(5):1510. doi: 10.3390/ijms19051510

Table 2.

Novel TP53 somatic mutations identified by NGS in six patients with HGSOC.

Case ID	Exon	Genomic Coordinate	Alt	Ref Read Depth	Alt Read Depth	cDNA Nucleotide Change	AA Change	Mutation Type
Case ID	Exon	Genomic Coordinate	(%) ^a	Ref Read Depth	Alt Read Depth	cDNA Nucleotide Change	AA Change	Mutation Type
305	7	17:7,577,541	58.43	15,734	9194	c.728_739delTGGGCGGCATGA	p.Met243_Met247del	In-frame
305	7	17:7,577,541	58.43	15,734	9194	c.728_739delTGGGCGGCATGA	p.Met243_Met247del	INDEL
519	8	17:7,577,128	47.84	6377	3051	c.795_809delGGGACGGAACAGCTT	p.Gly266_Phe270del	In-frame
519	8	17:7,577,128	47.84	6377	3051	c.795_809delGGGACGGAACAGCTT	p.Gly266_Phe270del	INDEL
627	8	17:7,577,111	22.34	4692	1048	c.826_827GC>AT	p.Ala276Ile	Missense
738	10	17:7,574,004	53.41	4606	2460	c.1022insT	p.Arg342Profs*5	Frameshift
738	10	17:7,574,004	53.41	4606	2460	c.1022insT	p.Arg342Profs*5	INDEL
751	11	17:7,572,928	8.32	2994	249	c.1180delT	p.Ter394Aspfs*28	Frameshift
751	11	17:7,572,928	8.32	2994	249	c.1180delT	p.Ter394Aspfs*28	INDEL
761	6	17:7,578,275	73.38	7205	5287	c.573insT	p.Gln192Serfs*17	Frameshift
761	6	17:7,578,275	73.38	7205	5287	c.573insT	p.Gln192Serfs*17	INDEL

^a Alternative allele frequency; NGS: next-generation sequencing; HGSOC: high-grade serous ovarian cancer; Ref: reference allele; Alt: alternative allele; AA: amino acid; fs: frameshift; del: deletion; ins: insertion; INDEL: insertion/deletion; Met: methionine; Gly: glycine; Phe: phenylalanine; Ala: alanine; Ile: isoleucine; Arg: arginine; Pro: proline; Ter: termination; Asp: aspartic acid; Gln: glutamine; Ser: serine.