Table 2.
Effects of peptides isolated from proteinase K lactoferrin hydrolysate (LFH) on prolyl endopeptidase (PEP) activity.
| Peptide (1 mg/mL) | Sequence | PEP Residual Activity (%) 1 |
|---|---|---|
| PKH1 | DRDQY | 102.7 ± 7.0 |
| PKH2 | VVKKGSNF | 115.0 ± 1.0 ** |
| PKH3 | ENLPEKA | 97.1 ± 0.1 |
| PKH4 | RIPSKV | 109.6 ± 2.2 * |
| PKH5 | GGRPTYEEY | 96.9 ± 2.1 |
| PKH6 | GILRPY | 97.2 ± 4.0 |
| PKH7 | DRDQYELL | 115.3 ± 4.2 ** |
| PKH8 | NEGLTW | 87.1 ± 1.0 ** |
| PKH9 | NIPMGL | 95.5 ± 3.4 |
| PKH10 | GILRPYL | 103.9 ± 0.8 |
| PKH11 | SVDGKEDLIW | 78.0 ± 3.1 ** |
1 Data are expressed as the percentage of PEP residual activity with respect to a control without peptide (100%) and are the mean ± SD of three replicates. * Significant inhibition with respect to control (p < 0.05). ** Significant inhibition with respect to control (p < 0.01) (Student’s t-test on absolute values of PEP activity).