Table 2.

Outcomes of intrasplenic islet transplantation.

Authors [Reference]	Publication Year	Transplant Model	Comments
Kolb E et al. [89]	1977	Auto (dog)	✓Achieved normoglycemia, but glucose tolerance was impaired
Feldman SD et al. [90]	1977	Auto (dog)	✓Achieved normoglycemia, but glucose tolerance was impaired ✓Implantation into splenic pulp
Gray BN et al. [92]	1979	Auto (dog)	✓Response of insulin and glucagon to arginine stimulation ✓Implantation into splenic pulp
Mehigan DG et al. [119]	1981	Auto (dog)	✓Assessment of quality of collagenase
Andersson A et al. [120]	1981	Iso (mouse)	✓Achieved normoglycemia after transplantation of 500 islets
Steffes MW et al. [121]	1981	Iso, allo (mouse)	✓Minimum of 13 weeks of nearly normal glucose levels after receiving skin grafts and spleen cells
Du Toit DF et al. [115]	1982	Allo (dog)	✓Extended survival, but normoglycemia not achieved
Janney CG et al. [116]	1982	Xeno (rat-to-mouse)	✓Prolongation of more than up to 100 days graft survival using cultured islets and administration of anti-mouse and/or anti-rat lymphocyte sera
Andersson A. [118]	1982	Allo (mouse)	✓Graft survival of several weeks with cultured islets but without immunosuppressants
Toledo-Pereyra LH et al. [103]	1983	Allo (dog)	✓Graft using cryopreserved islets was not rejected for more than 60 days
Warnock GL et al. [122]	1983	Iso (dog)	✓Five-month graft survival ✓Implantation via splenic vein
Andersson A [123]	1983	Iso (mouse)	✓Implantation of 500 islets was sufficient to achieve normoglycemia, while implantation of 150 islets was not
Merrell RC et al. [93,94]	1985	Auto (dog)	✓Achieved normoglycemia ✓Implantation via splenic vein
Kneteman NM et al. [124]	1985	Allo (dog)	✓Prolongation of graft survival (approximately 20 days) using cyclosporine
Gray DW et al. [113]	1986	Auto (monkey)	✓Achieved normoglycemia for 6 months ✓First report of monkey model
Gores PF et al. [95]	1987	Auto (dog)	✓Achieved normoglycemia for more than 30 days
Kneteman NM et al. [109]	1987	Allo (dog)	✓Achieved normoglycemia for more than 100 days using cyclosporine
Hayek A et al. [125]	1988	Iso (rat)	✓Partially achieved normoglycemia by transplantation of 1000 neonatal islets
Sutton R et al. [114]	1989	Auto (monkey)	✓Achieved normoglycemia with reduced insulin response
Evans MG et al. [96]	1989	Auto (dog)	✓The normoglycemic rate was 90% at 1 month after transplantation
van der Vliet JA et al. [97,98]	1989	Auto (dog)	✓Normoglycemic rate 63%
Warnock GL et al. [99]	1990	Auto (dog)	✓Normoglycemic rate 63% ✓Comparison between splenic vein and pulp as the route of transplantation. Intravenous route superior (normoglycemia rate 86% vs. 33%)
Ziegler B et al. [126]	1990	Iso (rat)	✓Achieved normoglycemia by transplantation of 1,200 islets
Korsgren O et al. [127]	1990	Iso (mouse)	✓Achieved normoglycemia by transplantation of 500 islets
Scharp DW et al. [100]	1992	Auto (dog)	✓Normoglycemic rats 86% at 1 year after transplantation
Motojima K et al. [101]	1992	Auto (dog)	✓Normoglycemia not achieved
Marchetti P et al. [102]	1993	Auto (dog)	✓Normoglycemic rate 90%, and decreased to 71% at 1 year after transplantation
Ao Z et al. [56]	1993	Auto (dog)	✓Normoglycemic rate 67%
Yakimets WJ et al. [117]	1993	Allo (dog)	✓Approximate 20 days graft survival using cyclosporine and rapamycin
Hesse UJ et al. [111]	1994	Auto (pig)	✓The normoglycemic rate was 50%.
Eizirik DL et al. [128]	1997	Xeno, allo (human and mouse-to-nude mouse)	✓Normoglycemia achieved by transplantation of 300 human islets into renal subcapsular space or 200 mouse islets into pulp of the spleen
Horton PJ et al. [77]	2000	Allo (dog)	✓Normoglycemia achieved by pre-transplant irradiation of total lymphocytes and donor-specific bone marrow transplantation