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Effects of drugs on mTORC1 and mTORC2 signaling on autophagy and cell proliferation. Pharmacological targets of first generation mTOR inhibitors (rapalogs; red), dual PI3K/mTOR inhibitors (green), second generation mTOR inhibitors (mTORKi; blue), and third generation mTOR inhibitors (Rapalink; blue) have been shown. Dashed/solid line T-bar: inibition; dashed/solid line arrow: activation.
