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. 2018 Apr 24;19(5):1278. doi: 10.3390/ijms19051278

Figure 3.

Figure 3

(A) Putative gate residues are depicted in the outward-occluded model of LAT1. F394 is the front doorway residue that corresponds to F350 of AdiC. S66 and F252 (proximal gate residues) of LAT1 correspond to S26 and W202 of AdiC. S342 (middle gate residue) of LAT1 corresponds to W293 of AdiC. N258, E136, and A409 (distal gate residues) of LAT1 correspond to E208, Y93, and Y365 of AdiC. The hydrogen bond interaction between E136 and N258 indicates a closed distal gate; (B) Hydrogen bond interactions of K204 (TM5) with G61 (TM1) and S334 (TM8) in the inward-open model of LAT1 based on the ApcT template (PDB ID: 3GI9) [40].