Figure 5.

Schematic representation of the rocking-bundle alternating-access mechanism for the sodium-coupled amino acid symporter LeuT. The core domain is shown in red/orange, and the scaffold domain is in blue. Further local conformational changes of the extracellular TM1b, TM6a (red), and TM7 (orange), and intracellular TM1a define the outside and inside gates, respectively. The two sodium ions are shown as green spheres, and the substrate is shown as a grey hexagon. This figure was recreated from reference [56].