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. 2018 May 16;19(5):1486. doi: 10.3390/ijms19051486

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Mechanisms of transcriptional regulation of Sp1 and hCtr1 in response to various challenges: (A) downregulation by Cu overload; (B) upregulation by Cu chelator; (C) upregulation by Cu(I) and cDDP combination.