Table 1.

Gene expression changes in csPIMT^−/− relative to PIMT^fl/fl mouse heart.

Function	Gene	KO/WT	KO/WT	KO/WT	KO/WT
		2 M, qPCR	2 M RNA-Seq	6 M, qPCR	6 M, RNA-Seq
OXPHOS
	Ndufaf4	0.35 *	0.21	0.18 **	0.20
	Ndufaf5	0.29 *	0.33	0.21 **	0.17
	Ndufs4	0.51 *	0.42	0.27 **	0.24
	Cox7b	0.32 *	0.27	0.36 *	0.41
	Cox10	0.59	0.27	0.25 **	0.28
	Sdha	0.63	0.52	0.41 *	0.37
	Sucla2	0.24 *	0.12	0.12 **	0.08
Energy metabolism/fatty acid
	Pparα	0.54	0.66	0.49	0.57
	Ppargc1a	0.51	0.36	0.55	0.45
	Acadm	0.36 *	0.39	0.12 **	0.27
	Ucp3	0.63	0.61	0.15 **	0.24
	Abcc9	0.61	0.67	0.16 *	0.49
Glucose metabolism
	Gck(GK)	3.93 *	1.97	2.46 *	3.87
	Pck1	1.88	4.23	0.51	0.63
	Pdk4	0.38 *	0.37	0.24 *	0.99
	HK2	0.74	0.97	0.45 *	0.83
	Glut4	0.59	0.92	0.36 *	0.78
Transcription factor, coactivator
	Med1	0.64	0.51	0.66	0.48
	NcoA6	0.69	0.66	0.57	0.62
	Tfam	0.47	0.25	0.19 **	0.48
Mitophagy/mitochondria fission
	Pink1	2.16 *	1.93	1.57	1.65
	Drp1	0.58	0.41	0.39 *	0.46
Cardiomyopathy/Fibrosis
	Tgfb2	0.66	0.91	9.41 **	5.23
	Ctgf	1.16	2.83	6.42 **	7.71
	Col9a2	3.24 *	6.42	8.33 **	26.06
	Fgf6	1.86	2.37	10.92 **	17.65
	Fgf21	2.35 *	3.08	5.18 **	6.22
	Mmp3	3.92 *	2.37	10.86 **	7.61
	Timp1	4.58 **	4.97	4.63 **	6.18
Hypertrophy/dilation
	Atf3	1.19	1.57	3.91 *	3.02
	Ace	2.69 *	2.23	3.78 *	6.48
	Wisp2	4.72 **	3.62	11.61 **	8.74
	Thbs4	5.91 **	6.68	9.34 **	8.56
Calcium homeostasis and signaling pathway
	Atp2b1	0.34 *	0.22	0.31 *	0.25
	Atp2a1	0.53	0.52	0.23 *	0.43
	Ryr2	0.65	0.53	0.14 **	0.54
	Map3k6	2.14	3.07	3.01 *	8.01
	Cacnb1	2.49 *	1.98	3.72 *	5.12
	Pde1c	0.38	0.21	0.21 **	0.14
	Cacna1h	0.29 *	0.23	0.19 **	0.01
	Mapk8	0.27 *	0.21	0.33 *	0.18

* p < 0.05, ** p < 0.01. KO, csPIMT^−/−; WT, PIMT ^fl/fl; M, months.