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. 2018 May 19;19(5):1518. doi: 10.3390/ijms19051518

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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CGA potentiates the Regorafenib-mediated growth inhibition by modifying cell cycle progression. PLC/PRF5 and HepG2 cells cultured with 1 µM (PLC/PRF/5) or 0.1 µM (HepG2) Regorafenib and 100 µM CGA alone or in combination, were synchronized in the S phase of the cell cycle using thymidine (0.2 M) (T0). After 3 h from blockrelease (T1), the cells were processed with the Cell Cycle Kit and analyzed with Muse Cell Analyzer to evaluate the percentage of cells in G0/G1, S and G2/M phases. An example of cell cycle progression in different treatment conditions are shown in the panels. The results of three independent experiments expressed as mean ± SD, are plotted in the relative graphs. * p < 0.05; ** p < 0.001*** p < 0.0001.